Droperidol


w122



General information:


Withdrawn ID: w122
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): N05AD08
Molecular Formula: C22H22FN3O2
Molweight: 379.427



Withdrawal information:


Withdrawn due to drug safety reasons:Yes
First approved: 1970
First withdrawn: 2001
Last withdrawn: 2001
Reference: https://www.ncbi.nlm.nih.gov/pubmed/15555999



Side-effects:

Total reported cases (submitted by medical professionals) with Droperidol as primary suspect: 60


Reported final outcomes:
Hospitalization (initial or prolonged): 28
Death: 18
Life-Threatening condition: 9
Intervention required to prevent permanent impairment/damage: 9
Disability: 2


Reported side-effects:

Side-effect Case number
Drug hypersensitivity20
DYSTONIA13
CARDIAC ARREST11
VENTRICULAR TACHYCARDIA10
TACHYCARDIA7
RESTLESSNESS7
AGITATION7
VENTRICULAR FIBRILLATION6
Hypotension6
Torsade de pointes5
Off label use5
Bradycardia5
ANXIETY5
RESPIRATORY ARREST4
Product label confusion4
NAUSEA4
FEELING ABNORMAL4
ELECTROCARDIOGRAM QT PROLONGED4
Dyspnoea4
DRUG INTERACTION4
CARDIO-RESPIRATORY ARREST4
Seizure3
SEDATION3
Product lot number issue3
PANIC REACTION3
MUSCLE TIGHTNESS3
CYANOSIS3
AKATHISIA3
Vomiting2
Syncope2
SUDDEN DEATH2
SOMNOLENCE2
SINUS BRADYCARDIA2
PULSE ABSENT2
PRURITUS2
NEUROLEPTIC MALIGNANT SYNDROME2
MUSCULOSKELETAL PAIN2
Hypertension2
HYPERHIDROSIS2
FEELING JITTERY2
FEAR2
Extrasystoles2
EXTRAPYRAMIDAL DISORDER2
DYSPHORIA2
Death2
CONVULSION2
CONDUCTION DISORDER2
Cardiotoxicity2
Bundle branch block left2
APNOEA2
APHASIA2
VITAL FUNCTIONS ABNORMAL1
Ventricular arrhythmia1
VENTRICLE RUPTURE1
Urticaria1
UPPER LIMB FRACTURE1
UPPER GASTROINTESTINAL HAEMORRHAGE1
TRISMUS1
TREATMENT FAILURE1
Tongue spasm1
Tongue movement disturbance1
THROAT TIGHTNESS1
TEARFULNESS1
SMALL INTESTINAL OBSTRUCTION1
SLEEP DISORDER1
SKIN WARM1
Sinus arrest1
SEROTONIN SYNDROME1
Restless legs syndrome1
RESPIRATORY RATE DECREASED1
PULSELESS ELECTRICAL ACTIVITY1
PULMONARY OEDEMA1
PULMONARY CONGESTION1
Psychomotor hyperactivity1
Product label issue1
Product barcode issue1
PROCEDURAL VOMITING1
PROCEDURAL COMPLICATION1
Poisoning1
Pleurothotonus1
Physical product label issue1
Peripheral swelling1
PARALYSIS1
PARAESTHESIA1
PANIC ATTACK1
Palpitations1
PAIN1
Oxygen saturation decreased1
Orthostatic hypotension1
Oropharyngeal swelling1
OROPHARYNGEAL DISCOMFORT1
OESOPHAGEAL RUPTURE1
NECK PAIN1
Myocardial infarction1
Muscle spasms1
MUSCLE RIGIDITY1
MUSCLE FATIGUE1
MOVEMENT DISORDER1
MALAISE1
Loss of consciousness1
Lip oedema1
INTERCEPTED DRUG ADMINISTRATION ERROR1
INADEQUATE ANALGESIA1
HYPONATRAEMIA1
HYPOAESTHESIA1
Heart rate increased1
HALLUCINATION, VISUAL1
Hallucination1
HAEMORRHAGE1
HAEMARTHROSIS1
GRAND MAL CONVULSION1
Flushing1
Fixed eruption1
FEELING HOT1
Fatigue1
FALL1
Expired product administered1
EXCORIATION1
EXCITABILITY1
Erythema1
Electrocardiogram T wave inversion1
ELECTROCARDIOGRAM T WAVE AMPLITUDE DECREASED1
Dysuria1
Dyskinesia1
Dysarthria1
DRUG TOXICITY1
DRUG INEFFECTIVE1
Drug abuse1
DISSOCIATION1
CONTRAINDICATION TO MEDICAL TREATMENT1
Confusional state1
Condition aggravated1
COMA1
Circumstance or information capable of leading to medication error1
Chest discomfort1
CATATONIA1
Cardiac failure congestive1
Cardiac failure1
Cannabinoid hyperemesis syndrome1
BURNING SENSATION1
BRUXISM1
BRAIN OEDEMA1
Brain injury1
Bradyarrhythmia1
BLOOD PRESSURE INCREASED1
Blood pressure fluctuation1
BLOOD PRESSURE DECREASED1
Blood potassium decreased1
Blood potassium abnormal1
BLOOD MAGNESIUM ABNORMAL1
Autoscopy1
AUTONOMIC NERVOUS SYSTEM IMBALANCE1
ATRIAL FIBRILLATION1
ATELECTASIS1
Arrhythmia1
Anaphylactic reaction1
Abdominal pain1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
P28482 4466.8 Mitogen-activated protein kinase 1 MK01_HUMAN
Q12809 32.2 Potassium voltage-gated channel subfamily H member 2 KCNH2_HUMAN
Q16665 3981.1 Hypoxia-inducible factor 1-alpha HIF1A_HUMAN



Toxicity information:

Toxicity type: cardiovascular



External links:

ChEBML: CHEMBL1108
DrugBank: DB00450